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KMID : 0376219830200020345
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Chonnam Medical Journal
1983 Volume.20 No. 2 p.345 ~ p.351
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The Fine Structure and Innervation of the Adrenal Medulla of the Mongolian Gerbil
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Abstract
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The fine structure and enervation of the chromaffin cells in the adrenal medulla of control and 5-hydroxydopamine-administrated Mongolian gerbil were studied by electron microscopy.
Using the glutaraldehyde-osmium tetroxide technique, noradrenaline and adrenaline-storing cells could be distinguished according to the character of their granules. Norepinephrine-storing granules were intensely osmiophilic and electron dense, while epinephrine -storing granules were only moderately electron-dense. The granular substance of chromaffin cells appeared to accumulate initially in the Golgi apparatus and extrude finally from the cell surface.
Only non-myelinated nerve fibers were observed innervating chromaffin cells. The intramedullary nerve bundles were found, to pass among chromaffin cells and vessels. Finally small groups of axon terminals entered into a group of chromaffin cells.
The cholinergic axon terminals contained mitochondria and small a granular vesicles which remained unchanged after the administration of 5-hydroxydopamine.
A great number of synaptic contacts between the cholinergic axon terminals and chromaffin cells were observed. They were either attached to the innervated cells or embedded into the cells, or connected to short spines of the cells.
One axon terminal was observed to innervate two or three epinephrine-and norepinephrine-storing cells.
The blood vessels of adrenal medulla were innervated by both cholinergic and adrenergic fibers.
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